In addition to the usual screening tests in suspected tox cases (BSL, ECG, paracetamol level) the following specific tests can be useful: 2-6 weeks –– chronic sequelae occur in survivors –– cirrhosis and gastrointestinal scarring and strictures.2-5 days –– acute heaptic failure, although rare mortality is high.12-48 hours –– Cellular toxicity becomes manifest as vasodilative shock and third-spacing, high anion gap metabolic acidosis (HAGMA) and hepatorenal failure.During this time iron shifts intracellularly from the circulation 6-12 hours –– gastrointestinal symptoms wane and the patient appears to be getting better.Significant fluid loseses may lead to hypovolemic shock 0-6 hours –– vomiting, diarrhoea, haemetemesis, melena, abdominal pain.Iron poisoning classically follows 5 stages, although the stages usually overlap, reflecting the two important phases of toxicity:Ĭlassic stages and time course of iron toxicity: ferrous sulfate (heptahydrate) - divide dose by 5.
0 Comments
Leave a Reply. |